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Conclusion. The AML patients with MLL-AF6 positive were mostly young, the majority of FAB types were M4 and M5, and most of the patients often had fever as the first symptom, with increased white blood cells, accompanied by organ infiltration, and high EVI1 gene expression. The hematological remission rate of routine chemotherapy is not low, …
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The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function …
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Regulation of development by MLL. In order to gain a better insight into the molecular function of MLL, several years ago, we purified its closest yeast homolog, Set1 (Miller et al. 2001).Yeast Set1 was found to exist as part of an ∼1-MDa complex named COMPASS with six other proteins named for their apparent molecular weight by SDS-PAGE: Cps25, …
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versely, MLL is not essential for the homeostasis of more differentiated myeloid and lymphoid cells [24]. These observations indicate that MLL is required for the prolifera-tion of immature hematopoietic progenitors. MLL is a large protein (431 kDa) possessing histone methyltransferase (HMT) activity on histone H3 lysine 4 [31, 32].
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Introduction. The KMT2A gene, better known as MLL (mixed lineage or myeloid/lymphoid leukemia) encodes a lysine (K)-specific histone methyltransferase 2A, which functions as an epigenetic regulator of transcription (Daniel and Nussenzweig, 2012; Takeda et al., 2013).The enzyme is primarily connected to hematopoietic and embryonic …
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MLL MVZ Postfach 20 14 53 80014 München. For courier services: MLL MVZ Max-Lebsche-Platz 31 81377 München. Address MLL Münchner Leukämielabor Max-Lebsche-Platz 31 81377 …
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„When a sample arrives at the MLL, it enters a world of extensive automation and digitization", writes Leah Lawrence in the Clinical News of the American Society of Hematology (ASH). With an innovative spirit of the times and state-of-the-art methods such as artificial intelligence, the team around Prof. Dr. Claudia Haferlach, Prof. Dr. Dr ...
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The human mixed lineage leukemia (MLL, MLL1, KMT2A) gene is disrupted by chromosomal translocations and other rearrangements in acute lymphoblastic leukemia and acute myeloid leukemia (AML) at high frequency in infants and lower frequencies in children and adults.Chromosomal translocations result in the fusion of the amino-terminal part of …
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Chromosomal translocations of MLL occur in aggressive acute leukemias affecting both children and adults. MLL fusion proteins require menin for leukemogenic activity, and selective targeting of the menin-MLL interaction represents a potential therapeutic approach for acute leukemias with MLL rearrangements. Here, we report the development of very …
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The human mixed lineage leukemia ( MLL, MLL1, KMT2A) gene is disrupted by chromosomal translocations and other rearrangements in acute lymphoblastic leukemia …
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MLL is involved in chromosomal translocations associated with leukemia. Remarkably, MLL is involved in translocations with >50 different genes (1, 2).MLL is specifically cleaved shortly after translation into two peptides that noncovalently associate with each other (3, 4).The amino-terminal portion of MLL contains a region with AT …
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Consistent with the lower sensitivity of ML2 leukemia cells, we found that depleting wild-type MLL in MM6 cells with a shRNA targeting the MLL C terminus reduces the sensitivity of …
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The AI tool developed at MLL, called the "MLL Predictor", helps physicians and scientists to assess whether a gene variant is pathogenic or benign or if its significance is still unclear based on the currently available worldwide …
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Chromosomal rearrangements involving the MLL gene have been associated with many different types of hematological malignancies. Most of them are easily recognized by conventional cytogenetics. However, in some cases, complex, unusual or cryptic rearrangements make the MLL involvement difficult or impossible to be detected …
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Disease latency varies with fusion partner in a mouse model of MLL leukemia. To better understand the direct roles of different MLL fusion proteins on transformation, cell lines were generated by transducing Kit + enriched mouse hematopoietic stem and progenitor cells with retroviruses encoding MLL-AF1p (distinct …
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MLL-menin-LEDGF interactions. Menin is one of several proteins that comprise the MLL core HMT complex. Originally identified as a product of the gene responsible for the heritable cancer syndrome multiple endocrine neoplasia type I, 21 menin interacts with the N-terminal part of MLL through a conserved binding motif. 22 Similar …
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Mixed lineage leukemia 1 (MLL1, also known as MLL or KMT2A) is an important transcription factor and histone-H3 lysine-4 (H3K4) methyltransferase. It is a …
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Clinical features of t(4;11) + infant B-ALL Infant MA4 + B-ALL is among the most vexing clinical problems in pediatric hematology/oncology. The incidence of MA4 + B-ALL in infant is between 1 and 2 logs lower than in children aged 1 to 14 years old. 1 Phenotypically, MA4 + B-ALL is a CD34 + CD19 + pro-B/mixed leukemia lacking CD10 …
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Cellular activity of MI-2-2 menin-MLL inhibitor in murine bone marrow cells transformed with various MLL fusions or control oncogenes. (a) Cell growth inhibition in MLL leukemia and control (transformed with E2A-HLF or Hoxa9/Meis1, HM-2) cell lines upon 10 days of treatment with MI-2-2.GI 50 values were assessed based on cell counts performed for …
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Results and Discussion. To determine the role of genetic diversity in MLL-AF9 leukemia, we crossed the Mll-AF9 knock-in mouse model 9 with the five distinct inbred strains A/J, C57BL/6 (B6), 129S1/SvlmJ (129), NOD/ShiLtJ (NOD) and CAST/EiJ (CAST). We studied F1 hybrid mice heterozygous for Mll-AF9 from these crosses versus the parental genetic …
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The mixed lineage leukemia (MLL) gene, located on chromosome 11q23, is frequently targeted by chromosomal translocations (see Krivtsov and Armstrong for a review; ref. 1).Balanced rearrangements result in the formation of new fusion proteins involved in childhood and adult de novo as well as therapy-related myeloid and …
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The study cohort. To analyze the recombinome of the human MLL gene, 2381 prescreened acute leukemia samples were obtained from the above-mentioned centers from 2003 to 2016. In all cases, we first ...
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MLL Dx in cooperation with the MLL Münchner Leukämielabor, served in a number of clinical trials as a diagnostic reference laboratory. We see ourselves as partners and diagnostic consultants to make a study clinically valuable as we have direct contact to the clinicians and know the needs of the daily clinic, treatments but also the requirements for …
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In mammals, the COMPASS-like complex KMTs are members of the mixed-lineage leukemia (MLL) family of proteins that contain the KMTase (also known as SET) …
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Accumulation of somatic mutations in mouse MLL -AML. To identify somatic mutations acquired during serial transplantation, we analyzed eight strains originated …
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Mixed lineage leukaemia (MLL) has histone methyltransferase activity and regulates the expression of genes such as Hox genes. This activity is lost in MLL fusion proteins resulting from inter ...
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To screen for miRNAs that can actually regulate MLL–AF4 mRNA expression, the MLL–AF4 3′ UTR was cloned into a modified pGL-3 control vector, thereby placing the 3′ UTR, which contains most ...
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The oncogenic function of MLL fusion proteins is critically dependent on their direct interaction with menin [17, 18].Menin is a 67 kDa protein encoded by the MEN1 (Multiple Endocrine Neoplasia I) gene localized on chromosome 11q13 [].Menin is an ubiquitously expressed protein, predominantly localized in the nucleus [].Menin directly binds to the N …
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Chromosomal rearrangements of the mixed lineage leukemia (MLL) gene occur in ∼10% of B-cell acute lymphoblastic leukemia (B-ALL) and define a group of patients with dismal outcomes.Immunohistochemical staining of bone marrow biopsies from most of these patients revealed aberrant expression of BCL6, a transcription factor that …
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Ambitious goals drive MLL's leadership and quality standards. The MLL Academy for employees is launching in the second half of 2021. From 2022 training will also be offered to external parties in the areas of business law and personal development. MLL's goal is to become an important training provider on the Swiss market for the next ...
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