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Smith LJ, Stapleton MR, Fullstone GJ, Crack JC, Thomson AJ, Le Brun NE, Hunt DM, Harvey E, Adinolfi S, Buxton RS, and Green J. Mycobacterium tuberculosis WhiB1 is an essential DNA-binding protein with a nitric oxide-sensitive iron-sulfur cluster. Biochem J 432: 417–427, 2010.
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Iron-sulfur cluster proteins exhibit a range of physicochemical properties that underpin their functional diversity in biology, which includes roles in electron transfer, catalysis, and gene regulation. Transcriptional regulators that utilize iron-sulfur clusters are a growing group that exploit the …
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The iron regulon in the well-studied budding yeast S. cerevisiae comprises a set of ∼30 genes that encode proteins involved in iron acquisition at the plasma membrane, iron import into the mitochondria, iron–sulfur cluster (ISC) biosynthesis, and vacuolar iron export [1, 2]. Upregulation of these genes in the face of iron deficit is ...
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Iron–sulfur (Fe–S) clusters are at the center of photosynthesis, respiration, amino acid, and DNA metabolism. Fe–S clusters are extraordinary catalysts, but their main components …
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Iron-sulfur (Fe/S) clusters belong to the most ancient protein cofactors in life, and fulfill functions in electron transport, enzyme catalysis, homeostatic regulation, and sulfur activation. The synthesis of Fe/S clusters and their insertion into apoproteins requires almost 30 proteins in the mitochondria and cytosol of eukaryotic cells. This ...
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Inspired by the fact that the active centers of natural nitrogenases are polynuclear iron-sulfur clusters, the reactivity of isolated iron-sulfur clusters toward N 2 has received considerable attention to gain fundamental insights into the activation of the N≡N triple bond. Herein, a series of gas-phase iron-sulfur cluster anions Fe x S y-(x = 1 …
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A University of Nebraska–Lincoln research team led by Limei Zhang, assistant professor of biochemistry, has been awarded a five-year, $1.8 million grant to …
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The iron-sulfur cluster (ISC) assembly complex is activated by frataxin (FXN) and Friedreich's ataxia is caused by FXN deficiency. Here the authors present the 3.2 Å resolution cryo-EM ...
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Initial iron and sulfur loading onto monomeric ISCU2 have been elucidated biochemically, yet subsequent [2Fe-2S] cluster formation and dimerization of ISCU2 is mechanistically ill-defined.
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The Flow Guard Iron/Sulfur Filter is a non-chemical solution to remove/reduce Iron/Manganese/ Sulfur (red and black stains or the rotten egg odor from your well water). How It Works. Water enters the Flow Guard Iron/Sulfur Filter and passes through the air chamber. This begins the oxidation of the iron, manganese or sulfur to a precipitated solid.
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The dominant electronic structural feature is the presence of high-spin Fe 3+ and Fe 2+ sites. The important mode of chemical reactivity is a simple one-electron transfer. Each of these features carries over to the 2Fe, …
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Transcriptional regulators that utilize iron-sulfur clusters are a growing group that exploit the redox and coordination properties of the clusters to act as sensors of …
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Categorize iron sulfur proteins based on the numbers of iron and inorganic sulfur atoms in the cluster. Analyze the structure of Fe-S clusters. Learn the characteristic features of iron-sulfur protein. Identify the biological role of iron sulfur proteins. Know the synthetic models of iron sulfur protein centres. 2. Introduction
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Introduction. Metabolic homeostasis is pivotal for the self-renewal and differentiation of hematopoietic stem and progenitor cells (HSPCs). 1, 2 Although hematopoietic stem cells (HSCs) are highly glycolytic, fine-tuned mitochondrial activity is indispensable for the maintenance of the HSC pool. 3, 4 Loss of Rieske iron-sulfur …
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Iron–sulfur (Fe-S) clusters are ubiquitous cofactors utilized by all realms of life, among which [2Fe-2S] and [4Fe-4S] clusters are the most commonly found in biological systems (1).These cofactors play a role in maintaining protein stability, as well as regulating subcellular localization and enzymatic activity (2, 3, 4).Being redox sensitive, these …
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Fe 4 S 4 Ferredoxins (including HiPIPs). We now turn our attention to proteins containing the Fe 4 S 4 center. Historically, within this class a strong distinction was made between the "ferredoxins," which are low-potential (as low as -600 mV in chloroplasts) iron-sulfur proteins, and the "HiPIPs" = High Potential Iron Proteins, which have positive redox …
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Iron(II) sulfide is a fascinating chemical compound that plays a significant role in various fields, including geology, chemistry, and industry. Made up of iron and sulfur, this compound is known for its dark, metallic appearance and is commonly found in the natural environment, especially within the earth's crust.Iron(II) sulfide is formed …
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The iron–sulphur (Fe–S) cofactor is essential for many enzymes critical for such 'adaptation'. The Mtb genome harbors only one putative iron–sulphur cluster (ISC) operon (rv1460-66 ...
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Regulatory proteins that contain an iron-sulfur cluster cofactor constitute a group that is growing both in number and importance, with a range of functions that include sensing of molecular oxygen, stress response, and iron regulation. In all cases, the cluster plays a central role, as a sensory mo …
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The story of the discovery of iron–sulfur clusters in eukaryotic DNA polymerases (Pols) begins with a genetic study of pol3–13 mutations involving mutations of one cysteine (Cys) of the second metal-binding motif of yeast Polδ to an alanine. The pol3–13 mutation was found to be synthetically lethal with mutations in the genes …
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Iron–sulphur (Fe–S) clusters have long been recognized as essential and versatile cofactors of proteins involved in catalysis, electron transport and sensing of ambient conditions. Despite the ...
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Husker team awarded $1.8M to investigate iron-sulfur redox mechanisms. November 18, 2020 . Science & Technology
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Iron–sulfur [FeS] clusters constitute one of the most versatile and ancient classes of bio-inorganic cofactors. In these clusters the Fe and S atoms exist in different stoichiometries and the ...
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Sulfide mineral precipitation occurs at mid-ocean ridge (MOR) spreading centers, both in the form of plume particles and seafloor massive sulfide structures. A common constituent of MOR is the iron-bearing sulfide mineral pyrrhotite, which was chosen as a substrate for in-situ incubation studies in …
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Iron-sulfur clusters [Fe-S] are small, ubiquitous inorganic cofactors representing one of the earliest catalysts during biomolecule evolution and are involved in fundamental biological reactions, including regulation of enzyme activity, mitochondrial respiration, ribosome biogenesis, cofactor biogenesis, gene expression regulation, and …
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Synthetic analogues of the active sites of iron-sulfur proteins Chem Rev. 2004 Feb;104(2):527-59. doi: 10.1021/cr020615+. Authors P Venkateswara Rao 1, R H Holm. Affiliation 1 Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA. PMID: 14871134 DOI: 10.1021 ...
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Iron-sulfur (Fe-S) clusters are inorganic prosthetic groups in proteins composed exclusively of iron and inorganic sulfide. These cofactors are required in a …
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Redox-active iron–sulfur clusters are ubiquitous in all forms of life and are usually involved in ... (Rv1280c-Rv1283c) from Mtb strain H37Rv was inserted into the pMV261 vector with a Flag tag ...
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A University of Nebraska–Lincoln research team led by Limei Zhang, assistant professor of biochemistry, has been awarded a five-year, $1.8 million grant to study the novel …
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In plants, the cysteine desulfurase (AtNFS1) and frataxin (AtFH) are involved in the formation of Fe-S groups in mitochondria, specifically, in Fe and sulfur loading onto scaffold proteins, and the subsequent formation of the mature Fe-S cluster. We found that the small mitochondrial chaperone, AtIS …
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